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Cryolipolysis for Fat Reduction and Body Contouring

Wellaholic Research: Cryolipolysis for Fat Reduction and Body Contouring

Background

Cryolipolysis is a nonsurgical technique for localized fat reduction. With the increased risk of complications from more invasive methods such as liposuction, cryolipolysis presents a promising method for nonsurgical body contouring. This study presents a systematic review of the available clinical data, with an emphasis on the efficacy, methods, safety, and complications of cryolipolysis.

In the bustling city of Singapore, a woman is availing the state-of-the-art WellaFreeze 360 fat freeze treatment at Wellaholic. This revolutionary treatment is designed to assist individuals in their journey towards achieving their desired body shape by targeting and eliminating stubborn fat cells through a process of controlled cooling. The WellaFreeze 360 fat freeze treatment is a non-surgical procedure that employs the principle of cryolipolysis to freeze and destroy fat cells, leaving the surrounding tissues unaffected. The body then naturally metabolizes and expels these dead cells over time, resulting in a more defined and contoured physique. The efficacy of the WellaFreeze 360 fat freeze treatment is well-documented. Numerous customers have reported noticeable changes after just a handful of sessions, making it a sought-after choice for those in pursuit of a safe and effective fat reduction technique.

Background of Research

Body contouring remains among the most common cosmetic surgical procedures performed in the United States. Data from the American Society for Aesthetic Plastic Surgery indicate that liposuction replaced breast augmentation as the most popular surgical procedure in 2013, with 363,912 procedures performed. Its popularity has grown considerably because of advantages such as aesthetic improvements as well as numerous metabolic benefits.1,2 Despite its popularity, there remain rare but significant risks regarding liposuction, including complications from anesthesia, infections, and even death.3 Clinical studies have reported a 21.7 percent incidence of minor complications as well as a 0.38 percent incidence of major complications.4,5 Similarly, Fischer et al. showed that the incidence of minor wound complications was 6.3 percent, and the incidence of a major morbidity was 6.8 percent within 30 days after a surgical body contouring procedure.6

Although liposuction is an effective therapeutic option for the removal of excess adipose tissue, it remains an invasive procedure and carries the inherent risks associated with surgery. In recent years, new modalities have been developed to address body contouring from a less-invasive perspective. These modalities primarily target the physical properties of fat that differentiate it from the overlying epidermis and dermis, thus resulting in selective destruction of fat. Devices using high-frequency ultrasound, radiofrequency energy, and laser light have the potential to improve efficiency, minimize adverse consequences, and shorten postoperative recovery time. Through thermal destruction, cavitational destruction, or creation of a temporary adipocyte cell membrane pore, the final result is that the number of adipocytes is reduced, which, when translated over millions of fat cells, results in a measurable reduction of fat.7

Cryolipolysis is one of the most recent forms of noninvasive fat reduction to emerge. The development behind cryolipolysis stems from the clinical observation of cold-induced panniculitis.810 In 1970, Epstein and Oren coined the term popsicle panniculitis after reporting the presence of a red indurated nodule followed by transient fat necrosis in the cheek of an infant who had been sucking on a popsicle.9 Initially described in infants, cold-induced panniculitis has also been observed in adult patients. These observations led to the concept that lipid-rich tissues are more susceptible to cold injury than the surrounding water-rich tissue. With these historical observations in mind, Manstein et al. introduced a novel noninvasive method for fat reduction with freezing in 2007, termed cryolipolysis.11 This technique is performed by applying an applicator to the targeted area set at a specific cooling temperature for a preset period of time. This targets adipocytes while sparing the skin, nerves, vessels, and muscles.

Initial preclinical and clinical studies have demonstrated the efficacy of cryolipolysis for subcutaneous fat layer reduction. However, the exact mechanism of action for cryolipolysis is not yet completely understood. In addition, the techniques of cryolipolysis treatment are not uniformly applied. Studies have suggested that the addition of posttreatment manual massage may enhance the effectiveness of a single cryolipolysis treatment, and that multiple treatments may lead to further improvement.12,13 Finally, we are currently still unaware of the long-term side effects and outcomes of this treatment. The aim of the present review was to give an overview of cryolipolysis with emphasis on the efficacy (volume reduction), methods, safety, and complications.

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In the bustling city of Singapore, a woman is availing the state-of-the-art WellaFreeze 360 fat freeze treatment at Wellaholic. This revolutionary treatment is designed to assist individuals in their journey towards achieving their desired body shape by targeting and eliminating stubborn fat cells through a process of controlled cooling. The WellaFreeze 360 fat freeze treatment is a non-surgical procedure that employs the principle of cryolipolysis to freeze and destroy fat cells, leaving the surrounding tissues unaffected. The body then naturally metabolizes and expels these dead cells over time, resulting in a more defined and contoured physique. The efficacy of the WellaFreeze 360 fat freeze treatment is well-documented. Numerous customers have reported noticeable changes after just a handful of sessions, making it a sought-after choice for those in pursuit of a safe and effective fat reduction technique.

Patients and Methods

A systematic review of the MEDLINE and Cochrane databases was performed with the search algorithm cryolipolysis OR cool sculpting OR fat freezing OR lipocryolysis. Two investigators independently reviewed article titles and abstracts to identify studies that assessed outcomes of cryolipolysis. Selected articles that met these inclusion criteria then underwent full article review by the two investigators. Additional articles were then identified by manual review of the references of the articles that were initially identified via the primary search. Review papers and animal studies were eliminated. A third investigator reconciled disagreements. The Cohen Kappa coefficient was calculated to demonstrate the level of agreement between the two initial investigators. The same two investigators performed data extraction independently, and any discrepancies were again reconciled by the third. Table ​Table11 lists the information extracted from each article.

Results

The primary literature search returned 319 articles (Fig. ​(Fig.1).1). The references of articles identified in the primary search were reviewed, yielding a total of 37 articles. Review papers and animal studies were eliminated, yielding a final number of 19 articles, including 12 prospective studies, three retrospective studies, one study with both prospective and retrospective groups, and three case reports. The Kappa coefficient was calculated at 0.885, indicating very good agreement between the investigators.

Efficacy

Common treatment areas included the abdomen, brassiere rolls, lumbar rolls, hip rolls/flanks, inner thighs, medial knee, peritrochanteric areas, arms, and ankles (Table ​(Table2).2). Follow-up length generally ranged from 2 to 6 months, although one study presented case reports on two patients at 2 and 5 years after treatment,14 noting persistent reduction at these time points when comparing pretreatment and posttreatment photographs. Objective outcome measures included fat caliper measurements, ultrasound measurements, and three-dimensional imaging (VECTRA M3; Canfield Scientific, Inc., Fairfield, N.J.). Every study that evaluated clinical outcomes using these outcome measures noted a significant reduction in fat volume in treatment areas (Table ​(Table3).3). Although outcomes varied greatly based on treatment site and study design, average reduction in caliper measurement ranged from 14.67 percent to 28.5 percent. Average reduction by ultrasound ranged from 10.3 percent to 25.5 percent (Table ​(Table3).3). Three studies evaluated lipid levels and liver function tests (Table ​(Table33).1517 No significant impact was noted on lipid levels or liver function tests after cryolipolysis treatments in any study.

Subjective assessments included both patient satisfaction rates and investigator assessments. In all cases, high satisfaction rates were noted, as demonstrated by posttreatment patient satisfaction surveys.13,15,16,1820 Only one of the reviewed studies used a validated survey to assess patient satisfaction.20 A clinically apparent difference was noted by posttreatment investigator assessments.13,15,16,18,20,21 Investigator assessments were based on whether or not there was an appreciable fat reduction. Blinded investigators were able to correctly differentiate between pretreatment and posttreatment images in 89 percent of cases in one study22 and 79 percent of cases in another.19 None of the studies reviewed included investigator assessments that specifically evaluated other factors, such as contour or texture.

The effect of posttreatment massage was evaluated in two studies. Sasaki et al. evaluated 5 minutes of posttreatment massage, noting an average fat reduction of 21.5 percent in treated areas by caliper measurement at 6 months.20 Another study by Boey and Wasilenchuk compared patients receiving 2 minutes of posttreatment manual massage to a control group receiving only the standard cryolipolysis treatment.12 At 2 months after treatment, average fat layer reduction was 68 percent greater on the massaged side (12.6 percent on the nonmassaged side versus 21.0 percent on the massaged side, p = 0.0007). However, at 4 months, average fat layer reduction was only 44 percent greater on the massaged side (10.3 percent on the nonmassaged side versus 14.9 percent on the massaged side, p = 0.1).12

The effect of multiple treatments has also been evaluated. In one study, patients receiving two treatments in the peritrochanteric area yielded an average fat layer reduction of 28.5 percent, compared with 19.7 percent in patients receiving only one treatment (p = 0.046).23 The effect of multiple treatments was evaluated on love handles and abdomens of patients in another study demonstrating different outcomes. Although a second treatment yielded a significant decrease in caliper measurements on the abdomen (p = 0.020), a statistically significant difference was not produced with a second treatment on the love handles (p = 0.084) (Table ​(Table33).13

Histologic outcomes were evaluated in a handful of studies. No evidence of fibrosis was noted in one study.12 Most studies demonstrate an inflammatory response at different stages after cryolipolysis, with inflammatory cell infiltrates peaking at 30 days,12 which led to adipocyte apoptosis.15 Biopsy specimens of peripheral nerve cells showed no long-term changes in peripheral nerves, with equal and normal numbers of epidermal nerves.21

In the bustling city of Singapore, a man is availing the state-of-the-art WellaFreeze 360 fat freeze treatment at Wellaholic. This revolutionary treatment is designed to assist individuals in their journey towards achieving their desired body shape by targeting and eliminating stubborn fat cells through a process of controlled cooling. The WellaFreeze 360 fat freeze treatment is a non-surgical procedure that employs the principle of cryolipolysis to freeze and destroy fat cells, leaving the surrounding tissues unaffected. The body then naturally metabolizes and expels these dead cells over time, resulting in a more defined and contoured physique. The efficacy of the WellaFreeze 360 fat freeze treatment is well-documented. Numerous customers have reported noticeable changes after just a handful of sessions, making it a sought-after choice for those in pursuit of a safe and effective fat reduction technique.

Conclusion

This study presents the first systematic review of the available data on cryolipolysis. Although the body of evidence is limited because of the nascence of this procedure, cryolipolysis is a promising procedure for nonsurgical fat reduction and body contouring. While the outcomes of cryolipolysis are rather modest, this technology is well suited for patients who desire nonsurgical spot reduction at modestly sized adiposities. Cryolipolysis appeals to both men and women and is an effective means by which new patients can be drawn to the aesthetic surgery practice.32 Although the specific mechanism of cryolipolysis has not been completely elucidated, this procedure appears to be effective and safe in the short term, with a limited side effect profile. Posttreatment manual massage has the potential to improve the efficacy of cryolipolysis. Multiple treatments in the same anatomic area may lead to further fat reduction, although the efficacy of cryolipolysis appears to be attenuated with successive treatments. The efficacy of this technique in areas that have been treated previously with liposuction remains to be studied. Future studies should address which treatment sites are most amenable to cryolipolysis to enhance treatment stratification for body contouring patients and should evaluate a potential role for cryolipolysis in skin tightening and the treatment of cellulite.

Source

With over 8 years of experience in the aesthetics industry, I am passionate about enhancing beauty and wellness through innovative, science-based approaches. As the Aesthetic Director at Wellaholic, I am committed to delivering exceptional services that are tailored to each client's unique needs. My expertise spans across advanced skincare treatments, body sculpting, hair removal services, and nutritional supplements, all aimed at helping clients achieve their personal best.

Serene Chiam, Aesthetic Director

Serene Chiam is the Aesthetic Director at Wellaholic, a well-known aesthetic chain in Singapore. She has more than ten years of experience in the aesthetics industry. With a Bachelor of Health Science (Aesthetics) and CIDESCO certifications, she expertly combines scientific knowledge with practical skills. Serene is known for her personalized approach to beauty, ensuring each Wellaholic client’s journey is unique and transformative. Her significant contributions have been pivotal in establishing Wellaholic’s reputation for excellence in aesthetic wellness.

Contact Serene at support@wellaholic.com

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Wellaholic Research: Unveiling the Impact of Cryolipolysis on Fat Reduction and Body Contouring in Singapore

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